Characterizing Deamidation and Oxidation in Adalimumab with Low pH Peptide Mapping and Middle-Up Mass Spec Analysis.

Chris Hosfield
Eric Largy
Anicet Catrain
Fabrice Cantais
Géry Van Vyncht
Michael Rosenblatt
Sergei Saveliev
Marjeta Urh
Arnaud Delobel
ASMS Sanibel Conference 2016

Non-enzymatic chemical modifications such as deamidation, oxidation and disulfide bond scrambling can affect the stability and efficacy of biotherapeutic proteins.