Characterisation of proteins by MS

Services
… range of technologies to fully characterise therapeutic proteins. Whether you are interested in monoclonal … antibodies (mAbs), antibody-drug conjugates (ADCs), fusion proteins, small or large proteins, Quality Assistance has the tools to support you for the characterisation of drug substances and drug products, QC …
Resources
… can be implemented for the efficient study of therapeutic protein glycosylation using analyses optimised for each … We presented efficient and optimized approaches for the characterisation of protein glycosylation by UPLC/mass spectrometry, based on …
Resources
… A large number of pharmaceuti cals are glycosylated proteins. An adequate glycosylati on is criti cal for therapeuti c proteins in terms of safety, bioacti vity, solubility, … dynamics. … … State-of-the art LC/MS methods applied to the characterisation of a highly-glycosylated fusion protein: …
Resources
… for each level of information you need (from intact protein to peptides/amino acids). Analytical performance of … is a very powerful technique widely used for the characterisation of biopharmaceuticals.  Thanks to … antibodies, based on three levels of analysis: Intact protein, mAb substructures (after IdeS / FabRICATOR …

Advanced Analytical Technologies for Proteins 2019

Events
…  will attend Advanced Analytical Technologies for Proteins! Topics will cover fundamental protein structure analysis for proteins from mammalian cell … Delobel, R&D Director, will present on the structural characterisation and epitope mapping by HDX-MS. Make sure …

Oligonucleotides: A serious analytical challenge in terms of analytical characterisation

Article
… Oligonucleotides: A serious challenge in terms of analytical characterisation by Arnaud Delobel , R&D Director at Quality … a GMP/GLP environment. Though less complex than recombinant proteins, oligonucleotides represent a serious challenge in … available for the characterisation of peptide and protein drugs are constantly improving, less focus is put on …
Resources
… We presented efficient and optimised approaches for the characterisation of ADCs by mass spectrometry, based on different levels of analysis:  Intact protein for Drug-to-Antibody Ratio determination … information you need.  … Mass Spectrometry Toolkit for the characterisation of ADCs … resource …