Characterisation of proteins by MS
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… in monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), fusion proteins, small or large proteins, Quality …
Mass Spectrometry Protein Characterisation Specialist
Jobs
… to large molecules Very good knowledge of analysis of peptides/proteins/mAbs by High Resolution Mass Spectrometry … audits and investigations … Very good knowledge of peptides/proteins/mAbs analysis by High Resolution Mass …
Resources
… can be implemented for the efficient study of therapeutic protein glycosylation using analyses optimised for each … We presented efficient and optimized approaches for the characterisation of protein glycosylation by UPLC/mass spectrometry, based on …
Resources
… A large number of pharmaceuti cals are glycosylated proteins. An adequate glycosylati on is criti cal for therapeuti c proteins in terms of safety, bioacti vity, solubility, … dynamics. … … State-of-the art LC/MS methods applied to the characterisation of a highly-glycosylated fusion protein: …
Resources
… and have developed a set of analytical workflows for the characterisation of biotherapeutics , with a strong focus … on: monoclonal antibodies antibody-drug conjugates fusion proteins These workflows can serve as generic methods in … sound expertise in Mass Spectrometry. … Mass Spectrometry protein characterisation at Quality Assistance … resource …
PEGylated Proteins
Services
… Protein PEGylation is a great tool to improve the delivery of therapeutic proteins, but it adds a level of complexity to the product. As well as the characterisation of individual components (PEG and protein), …
Resources
… Host-cell proteins are a major class of process-related impurities in … test. This application note describes an approach for the characterisation of anti-HCP antibodies, and particularly … be used for routine testing of residual HCPs in therapeutic proteins is appropriate. Compared to traditional Western …
Resources
… use of mass spectrometry as a powerful tool for adalimumab characterisation is presented. Humira ® (adalimumab) is an … recombinant antibody expressed in CHO cells. As for all proteins produced via recombinant DNA technologies, the … a technique that is now widely used for biopharmaceuticals characterisation. Thanks to innovations in both hardware and …
Resources
… Monoclonal antibodies (mAbs) represent a large part of pharmaceuticals currently … ~25 kDa connected by disulphide bridges. The production of mAbs is a lengthy and complex process. It is, however, … would be of great benefit to quickly characterise mAbs. Typical modifications followed during the production …