Characterisation of proteins by MS
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… in monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), fusion proteins, small or large proteins, Quality …
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… can be implemented for the efficient study of therapeutic protein glycosylation using analyses optimised for each … We presented efficient and optimized approaches for the characterisation of protein glycosylation by UPLC/mass spectrometry, based on …
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… and have developed a set of analytical workflows for the characterisation of biotherapeutics , with a strong focus … on: monoclonal antibodies antibody-drug conjugates fusion proteins These workflows can serve as generic methods in … sound expertise in Mass Spectrometry. … Mass Spectrometry protein characterisation at Quality Assistance … resource …
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… A large number of pharmaceuti cals are glycosylated proteins. An adequate glycosylati on is criti cal for therapeuti c proteins in terms of safety, bioacti vity, solubility, … dynamics. … … State-of-the art LC/MS methods applied to the characterisation of a highly-glycosylated fusion protein: …
LAB R&D SCIENTIST – Characterisation of biomolecules
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… Very good technical expertise in (U)HPLC applied to peptides and proteins Very good practical knowledge of one … Very good knowledge of analysis and characterisation of peptides/proteins/mAbs, oligonucleotides, mRNA and/or viral … … Very good technical expertise in (U)HPLC applied to peptides and proteins. Very good practical knowledge of one …
PEGylated Proteins
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… Protein PEGylation is a great tool to improve the delivery of therapeutic proteins, but it adds a level of complexity to the product. As well as the characterisation of individual components (PEG and protein), …
Resources
… Host-cell proteins are a major class of process-related impurities in … . This webcast describes an alternative approach for the characterisation of the HCP coverage of these anti-HCP … be used for routine testing of residual HCPs in therapeutic proteins is appropriate. Compared to traditional Western …
Resources
… use of mass spectrometry as a powerful tool for adalimumab characterisation is presented. Humira ® (adalimumab) is an … recombinant antibody expressed in CHO cells. As for all proteins produced via recombinant DNA technologies, the … a technique that is now widely used for biopharmaceuticals characterisation. Thanks to innovations in both hardware and …