Our webinar is online: Mass spectrometry toolkit for the characterisation of protein glycosylation
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… Due to their mode of production, therapeutic glycoproteins present complex and heterogeneous glycosylations. …
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… to mAbs (Humira ® , Erbitux ® ) and highly glycosylated proteins (Enbrel ® ) will be presented. The performances …
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… and have developed a set of analytical workflows for the characterisation of biotherapeutics , with a strong focus … on: monoclonal antibodies antibody-drug conjugates fusion proteins These workflows can serve as generic methods in … sound expertise in Mass Spectrometry. … Mass Spectrometry protein characterisation at Quality Assistance … resource …
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… A large number of pharmaceuti cals are glycosylated proteins. An adequate glycosylati on is criti cal for therapeuti c proteins in terms of safety, bioacti vity, solubility, … dynamics. … … State-of-the art LC/MS methods applied to the characterisation of a highly-glycosylated fusion protein: …
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… Therapeutic Protein Charge Variants Characterisation using icIEF fractionation and MS … resource …
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… A novel trypsin for accurate characterisation of biotherapeutic proteins with peptide mapping … resource …
PEGylated Proteins
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… is a great tool to improve the delivery of therapeutic proteins, but it adds a level of complexity to the product. … In addition to all the analytical tests proposed for proteins, Quality Assistance has developed specific methods for the analysis of PEGylated proteins using state-of-the-art analytical techniques, such …
Product characterisation by High-Resolution Mass Spectrometry (HRMS)
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… Mass Spectrometry (HRMS) solutions to support the characterisation of a wide range of therapeutic modalities. … range of technologies to fully characterise therapeutic proteins. … Product characterisation by High-Resolution Mass Spectrometry (HRMS) …
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… Host-cell proteins are a major class of process-related impurities in … . This webcast describes an alternative approach for the characterisation of the HCP coverage of these anti-HCP … be used for routine testing of residual HCPs in therapeutic proteins is appropriate. Compared to traditional Western …
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… use of mass spectrometry as a powerful tool for adalimumab characterisation is presented. Humira ® (adalimumab) is an … recombinant antibody expressed in CHO cells. As for all proteins produced via recombinant DNA technologies, the … a technique that is now widely used for biopharmaceuticals characterisation. Thanks to innovations in both hardware and …