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Characterisation of proteins by MS

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… range of technologies to fully characterise therapeutic proteins. Whether you are interested in monoclonal … antibodies (mAbs), antibody-drug conjugates (ADCs), fusion proteins, small or large proteins, Quality Assistance has the tools to support you for the characterisation of drug substances and drug products, QC …

Mass Spectrometry Protein Characterisation Specialist

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… to large molecules Very good knowledge of analysis of peptides/proteins/mAbs by High Resolution Mass Spectrometry … audits and investigations … Very good knowledge of peptides/proteins/mAbs analysis by High Resolution Mass …

Our webinar is online: Mass spectrometry toolkit for the characterisation of protein glycosylation

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… Assistance webinar Mass spectrometry toolkit for the characterisation of protein glycosylation given on July 12th at 16.00 … Due to their mode of production, therapeutic glycoproteins present complex and heterogeneous glycosylations. …

Mass spectrometry toolkit for the characterisation of protein glycosylation

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… can be implemented for the efficient study of therapeutic protein glycosylation using analyses optimised for each … We presented efficient and optimized approaches for the characterisation of protein glycosylation by UPLC/mass spectrometry, based on …

State-of-the art LC/MS methods applied to the characterisation of a highly-glycosylated fusion protein: Etanercept

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… A large number of pharmaceuti cals are glycosylated proteins. An adequate glycosylati on is criti cal for therapeuti c proteins in terms of safety, bioacti vity, solubility, … dynamics. … … State-of-the art LC/MS methods applied to the characterisation of a highly-glycosylated fusion protein: …

Mass Spectrometry protein characterisation at Quality Assistance

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… and have developed a set of analytical workflows for the characterisation of biotherapeutics , with a strong focus … on: monoclonal antibodies antibody-drug conjugates fusion proteins These workflows can serve as generic methods in … sound expertise in Mass Spectrometry. … Mass Spectrometry protein characterisation at Quality Assistance … resource …

PEGylated Proteins

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… Protein PEGylation is a great tool to improve the delivery of therapeutic proteins, but it adds a level of complexity to the product. As well as the characterisation of individual components (PEG and protein), …

Characterisation of Anti-HCP antibodies by 2D differential Gel Electrophoreses

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… Host-cell proteins are a major class of process-related impurities in … test. This application note describes an approach for the characterisation of anti-HCP antibodies, and particularly … be used for routine testing of residual HCPs in therapeutic proteins is appropriate. Compared to traditional Western …

Characterisation of Humira Adalimumab by high resolution mass spectrometry

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… use of mass spectrometry as a powerful tool for adalimumab characterisation is presented. Humira ® (adalimumab) is an … recombinant antibody expressed in CHO cells. As for all proteins produced via recombinant DNA technologies, the … a technique that is now widely used for biopharmaceuticals characterisation. Thanks to innovations in both hardware and …

New 2D-LC/MS approaches for the analysis of in-process samples and for the characterisation of mAbs in a regulated environment

Resources

… However, these steps are time consuming while fast characterisation is expected. On-line purification and … here and describe the use of a 2D-LC system for MS characterisation of mAbs without sample preparation. In the first application, a Protein A affinity column allows MS characterisation of mAbs …