Scientific Library

Welcome to our scientific library!

Explore more of our expertise, R&D findings and analytical know-how by accessing this large portfolio of documents compiling both technical and regulatory information.

Study & Technical sheets

  • Surface Plasmon Resonance

    Biacore technology offers label-free assays that provide precise and reliable concentration and kinetic measurement. This can be applied through all stages of product development, from discovery to quality control.
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  • Bioassays

    Quality Assistance is specialised in the development and/or optimisation, validation and transfer of a very wide range of potency assays.
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Scientific posters

Characterisation of monoclonal antibodies in cell supernatants by 2D-LC/MS

Authors
Claire I. Butré
Camille Allain
Arnaud Delobel
Location
Analytical Technologies Europe 2020 & Antibody Industrial Symposium 2020
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Development of characterisation and potency assays for immunotherapy products

Authors
Fabian Vandermeers
Sandra Thys
Thomas Henri
Mike Collodoro (PDC*LINE PHARMA)
Arnaud Delobel
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Oligonucleotides: Absolute quantification and P=O/P=S in a single ICP-MS/MS run

Authors
Juliusz Bianga
Philippe De Raeve
Arnaud Delobel
Caroline Cajot
Location
TIDES 2018
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Epitope mapping of an interleukin receptor for three therapeutic antibodies by HDX-MS

Authors
Eric Largy
Caroline Cajot
Arnaud Delobel
Location
Analytical Technologies Europe 2018
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Publications & Application notes

New 2D-LC/MS approaches for the analysis of in-process samples and for the characterisation of mAbs in a regulated environment

Monoclonal antibodies (mAbs) represent a large part of pharmaceuticals currently under development. Monoclonal antibodies are 150 kDa molecules consisting of two heavy chains of ~50 kDa and two light chains of ~25 kDa connected by disulphide bridges.

Authors
Dr. Arnaud Delobel
Claire I. Butré
Camille Alain
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Charge variants analysis of monoclonal antibodies

Charge variants are considered as a Critical Quality Attribute of therapeutic monoclonal antibodies, as they can have a significant impact on the efficacy of the drug. State-of-the-art analytical techniques are required to both quantify and identify the variants. In this application note, we present the portfolio proposed by Quality Assistance, including capillary isoelectric focusing (cIEF) and ion-exchange chromatography (IEX), with applications to commercial monoclonal antibodies. Approaches based on (2D-)LC/MS are presented for the identification of the variants.
Authors
Dr. Arnaud Delobel
Claire I. Butré
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Webinars

Conferences

Quality Assistance waters dublin webaf

Multiple Heartcut 2D-LC/MS: a powerful tool for biopharma analysis in a regulated environment

Multiple Heartcut 2D-LC/MS is a powerful tool for biopharma analysis in a regulated environment.
Authors
Dr Arnaud Delobel, R&D Director
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Adebiotech AATP Proteins Delobel Quality Assistance

Structural characterisation and epitope mapping by HDX-MS

Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) is an innovative tool for the characterisation of biotherapeutics.
Authors
Dr Arnaud Delobel
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