Scientific Library
Welcome to our scientific library!
Explore more of our expertise, R&D findings and analytical know-how by accessing this large portfolio of documents compiling both technical and regulatory information.
Study & Technical sheets
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Surface Plasmon Resonance
Biacore technology offers label-free assays that provide precise and reliable concentration and kinetic measurement. This can be applied through all stages of product development, from discovery to quality control.Download the full document -
Bioassays
Quality Assistance is specialised in the development and/or optimisation, validation and transfer of a very wide range of potency assays.Download the full document -
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Scientific posters
Characterisation of monoclonal antibodies in cell supernatants by 2D-LC/MS
Location
Analytical Technologies Europe 2020 & Antibody Industrial Symposium 2020
Development of characterisation and potency assays for immunotherapy products
Download the posterOligonucleotides: Absolute quantification and P=O/P=S in a single ICP-MS/MS run
Location
TIDES 2018
Epitope mapping of an interleukin receptor for three therapeutic antibodies by HDX-MS
Location
Analytical Technologies Europe 2018
Publications & Application notes
New 2D-LC/MS approaches for the analysis of in-process samples and for the characterisation of mAbs in a regulated environment
Monoclonal antibodies (mAbs) represent a large part of pharmaceuticals currently under development. Monoclonal antibodies are 150 kDa molecules consisting of two heavy chains of ~50 kDa and two light chains of ~25 kDa connected by disulphide bridges.
Charge variants analysis of monoclonal antibodies
Charge variants are considered as a Critical Quality Attribute of therapeutic monoclonal antibodies, as they can have a significant impact on the efficacy of the drug. State-of-the-art analytical techniques are required to both quantify and identify the variants. In this application note, we present the portfolio proposed by Quality Assistance, including capillary isoelectric focusing (cIEF) and ion-exchange chromatography (IEX), with applications to commercial monoclonal antibodies. Approaches based on (2D-)LC/MS are presented for the identification of the variants.
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Webinars
The production of monoclonal antibodies (mAbs) is a lengthy and complex process. It is, however, important to follow the mAb during
During this live webinar, we will outline the different analytical workflows that can be used for charge variant analysis (ion-exchange chromatography with salt or pH gradients, MS-compatible approaches, 2D-LC/MS, and icIEF) and present several case studies.
Access this 15 minutes webcast to learn more about an analytical method we have developed in our labs for the absolute quantification of proteins by ICP/MS.
Access this 15 minutes webcast to learn more about our large capacity and sound expertise in Mass Spectrometry.
Access this 45 minutes webinar to learn how ICP/MS can be used for the absolute quantification of proteins, with precision and accuracy that cannot be reached with amino acid analysis.
Access this 20 minutes webcast to learn how Quality Assistance developed an ICP-MS/MS method based on the quantification of P and S after microwave digestion to determine the P=O/P=S ratio in oligonucleotide samples.
Access this 45 minutes webinar to learn how HDX-MS can be applied throughout the development of your product to get structural information that can hardly be obtained with other techniques.
After a detailed description of the technique and its applications, case studies will be presented in the context of comparability and epitope mapping studies.
Access this 45 minutes webinar to learn how to characterise pluripotent stem cells in terms of identity and purity. The analytical performance of the methods developed have been discussed along with the presentation of experimental results obtained during method development, optimisation and/or validation.
Access this 45 minute webinar to learn how to characterise human mesenchymal stem cells in terms of identity, purity and biological activity. The analytical performance of the methods developed have been discussed along with the presentation of experimental results obtained during method development, optimisation and/or validation.
Join this 45 minute webinar to learn how to overcome the challenges usually associated to Multiplex assays and how to select the right technology for your needs.
Access this 45 minute webinar to learn how state-of-the-art LC/MS technologies can be implemented for the efficient study of therapeutic protein glycosylation using analyses optimised for each level of information you need.
Access this 45 minute webinar to learn how Surface Plasmon Resonance can be implemented in a GMP regulated environment for the comprehensive study of monoclonal antibodies and other Biologics.
Access this 45 minute webinar to learn how state-of-the-art LC/MS technologies can be implemented for the efficient study of ADCs using analyses optimised for each level of information you need.
Access this 45 minute webinar to learn how state-of-the-art LC/MS technologies can be implemented for the efficient study of monoclonal antibodies using analyses optimised for each level of information you need (from intact protein to peptides/amino acids).
Access this 30 minute webinar to learn how the Q3D guideline for EIs can be efficiently implemented for all drug substances, excipients and drug products.
Access this webinar which presented how the Q3D guideline for EIs can be efficiently implemented for all drug substances, excipients and drug products.
Although drug products issued from biotechnology have now been on the market for many years, accurate protein quantification remains a
Conferences
Multiple Heartcut 2D-LC/MS: a powerful tool for biopharma analysis in a regulated environment
Multiple Heartcut 2D-LC/MS is a powerful tool for biopharma analysis in a regulated environment.
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Structural characterisation and epitope mapping by HDX-MS
Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) is an innovative tool for the characterisation of biotherapeutics.
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