Scientific Library

Welcome to our scientific library!

Explore more of our expertise, R&D findings and analytical know-how by accessing this large portfolio of documents compiling both technical and regulatory information.

Study & Technical sheets

  • Surface Plasmon Resonance

    Biacore technology offers label-free assays that provide precise and reliable concentration and kinetic measurement. This can be applied through all stages of product development, from discovery to quality control.
  • Bioassays

    Quality Assistance is specialised in the development and/or optimisation, validation and transfer of a very wide range of potency assays.
  • Luminex

    Multiple biomolecules quantification in biological fluids
  • Cytokine Release

    Comparison of multiplex and simplex assays

Scientific posters

Development of characterisation and potency assays for immunotherapy products

Authors
Fabian Vandermeers
Sandra Thys
Thomas Henri
Mike Collodoro (PDC*LINE PHARMA)
Arnaud Delobel

Oligonucleotides: Absolute quantification and P=O/P=S in a single ICP-MS/MS run

Authors
Juliusz Bianga
Philippe De Raeve
Arnaud Delobel
Caroline Cajot
Location
TIDES 2018

Epitope mapping of an interleukin receptor for three therapeutic antibodies by HDX-MS

Authors
Eric Largy
Caroline Cajot
Arnaud Delobel
Location
Analytical Technologies Europe 2018

Bioanalysis of 9 elemental impurities in human whole blood and urine samples by ICP-MS

Authors
Olivier Lurkin
Albin Jouran
Marie-Odile Galcera
Stéphane Frécinaux
Location
EBF Open Symposium 2017

Publication & Application notes

Development, optimisation and validation of a TNFα neutralising assay using a Quality by Design approach

Using a QbD approach, we developed a TNFα neutralising assay capable of fulfilling the Analytical Target Profile. Statistical Design of Experiment was applied to evaluate the effect of the different factors and to choose the optimal parameters.

Authors
Fabian Vandermeers
Capucine Lepers
Florence Dusserre-Bresson
Christelle Plennevaux
Stéphanie Pennincx
Julie Nicaise
Estelle Lara
Vincent Bertholet
Arnaud Delobel

Innovative ICP-MS/MS approach for the determination of phosphodiester to phosphorothioate ratio in phosphorothioate oligonucleotides

Phosphodiester to phosphorothioate ratio (P=O/P=S) is a critical quality attribute of phosphorothioate oligonucleotides. The determination of this ratio is commonly performed by P-NMR, which requires specific equipment and cannot be easily applied in a regulated (GxP) environment.

Authors
Juliusz Bianga
Caroline Cajot
Philippe De Raeve
Arnaud Delobel

Webinars

Conferences

Quality Assistance glycosylation proteins

Orthogonal LC/MS methods for the comprehensive characterisation of therapeutic glycoproteins

Glycosylation is critical for the safety and efficacy of biotherapeutics.

Authors
Dr Arnaud Delobel, R&D Director
quality assistance ICP scientist

Absolute quantification of mAbs and ADCs : forget amino acid analysis and shift to the new gold standard

Absolute quantification of mAbs and ADCs: Quality Assistance developed an innovative analytical method based on sulfur quantification by ICP-MS/MS
 

Authors
Dr Arnaud Delobel, R&D Director