Scientific Library

Welcome to our scientific library!

Explore more of our expertise, R&D findings and analytical know-how by accessing this large portfolio of documents compiling both technical and regulatory information.

Study & Technical sheets

  • Luminex

    Multiple biomolecules quantification in biological fluids
  • Cytokine Release

    Comparison of multiplex and simplex assays
  • PEGylated Proteins

    In addition to all the analytical tests proposed for proteins, Quality Assistance has developed specific methods for the analysis of PEGylated proteins.
  • In-use stability studies

Scientific posters

Oligonucleotides: Absolute quantification and P=O/P=S in a single ICP-MS/MS run

Authors
Juliusz Bianga
Philippe De Raeve
Arnaud Delobel
Caroline Cajot
Location
TIDES 2018

Epitope mapping of an interleukin receptor for three therapeutic antibodies by HDX-MS

Authors
Eric Largy
Caroline Cajot
Arnaud Delobel
Location
Analytical Technologies Europe 2018

Bioanalysis of 9 elemental impurities in human whole blood and urine samples by ICP-MS

Authors
Olivier Lurkin
Albin Jouran
Marie-Odile Galcera
Stéphane Frécinaux
Location
EBF Open Symposium 2017

Mass Spectrometry as a tool for the Bioanalysis of Antibody-Drug Conjugates (ADCs)

Authors
Stéphane Frécinaux
Arnaud Delobel
Location
EBF Open Symposium 2017

Publication & Application notes

Development, optimisation and validation of a TNFα neutralising assay using a Quality by Design approach

Using a QbD approach, we developed a TNFα neutralising assay capable of fulfilling the Analytical Target Profile. Statistical Design of Experiment was applied to evaluate the effect of the different factors and to choose the optimal parameters.

Authors
Fabian Vandermeers
Capucine Lepers
Florence Dusserre-Bresson
Christelle Plennevaux
Stéphanie Pennincx
Julie Nicaise
Estelle Lara
Vincent Bertholet
Arnaud Delobel

Innovative ICP-MS/MS approach for the determination of phosphodiester to phosphorothioate ratio in phosphorothioate oligonucleotides

Phosphodiester to phosphorothioate ratio (P=O/P=S) is a critical quality attribute of phosphorothioate oligonucleotides. The determination of this ratio is commonly performed by P-NMR, which requires specific equipment and cannot be easily applied in a regulated (GxP) environment.

Authors
Juliusz Bianga
Caroline Cajot
Philippe De Raeve
Arnaud Delobel

Webinars

Conferences

Orthogonal LC/MS methods characterisation therapeutic glycoproteins Arnaud Delobel Quality Assistance

Orthogonal LC/MS methods for the comprehensive characterisation of therapeutic glycoproteins

Glycosylation is critical for the safety and efficacy of biotherapeutics.

Authors
Arnaud Delobel

Q3D - Elemental Impurities

What implications for APIs & excipients suppliers?

15th Oct 2015
Authors
Philippe De Raeve, Scientific Director