Webinar

monoclonal antibodies Quality Assistance

Analytical workflows for charge variant analysis of monoclonal antibodies

The analytical characterisation of monoclonal antibodies is complex and requires a wide range of techniques, due to high heterogeneity of these proteins.

Authors
Dr. Arnaud Delobel
Quality Assistance icpms

Absolute quantification of proteins: forget amino acid analysis and shift to the new gold standard

Absolute quantification of proteins (i.e. quantification without the need for a reference standard) is a key analysis for the qualification of reference standards or to determine the extinction coefficient of a protein. It is usually performed using amino acid analysis, but this techniqu

Authors
Dr. Arnaud Delobel
Quality Assistance Mass Spectrometry BioAccord

Mass Spectrometry protein characterisation at Quality Assistance

Quality Assistance has a large capacity and a sound expertise in Mass Spectrometry.

Authors
Dr. Arnaud Delobel

Absolute quantification of mAbs and ADCs: forget amino acid analysis and shift to the new gold standard

Absolute quantification of proteins (i.e. quantification without the need for a reference standard) is a key analysis for the qualification of reference standards or to determine the extinction coefficient of a protein. It is usually performed using amino acid an

Authors
Dr Arnaud Delobel

HDX-MS a powerful tool for biopharmaceutical characterisation

Access this 45 minutes webinar to learn how HDX-MS can be applied throughout the development of your product to get structural information that can hardly be obtained with other techniques.

Authors
Dr Arnaud Delobel

Conference

Quality Assistance waters dublin webaf

Multiple Heartcut 2D-LC/MS: a powerful tool for biopharma analysis in a regulated environment

Multiple Heartcut 2D-LC/MS is a powerful tool for biopharma analysis in a regulated environment.

Authors
Dr Arnaud Delobel, R&D Director
Adebiotech AATP Proteins Delobel Quality Assistance

Structural characterisation and epitope mapping by HDX-MS

Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) is an innovative tool for the characterisation of biotherapeutics.

Authors
Dr Arnaud Delobel
Quality Assistance glycosylation proteins

Orthogonal LC/MS methods for the comprehensive characterisation of therapeutic glycoproteins

Glycosylation is critical for the safety and efficacy of biotherapeutics.

Authors
Dr Arnaud Delobel, R&D Director

Publication & Application note

Development, optimisation and validation of a TNFα neutralising assay using a Quality by Design approach

Authors
Fabian Vandermeers
Capucine Lepers
Florence Dusserre-Bresson
Christelle Plennevaux
Stéphanie Pennincx
Julie Nicaise
Estelle Lara
Vincent Bertholet
Arnaud Delobel

Stress testing of Humira (adalimumab) monitored by Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS)

Authors
Eric Largy
Arnaud Delobel

Epitope mapping of an interleukin receptor for three therapeutic antibodies by Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS)

Authors
Eric Largy
Caroline Cajot
Arnaud Delobel

Analytical approaches for the evaluation of ADCC activity of mAbs

Authors
Arnaud Delobel
Florence Dusserre-Bresson
Eric Largy
Capucine Lepers
Cléa Mantini
Christelle Plennevaux
Fabian Vandermeers

Customised labelling of antibodies: A powerful tool for multi-parameters analyses in Flow Cytometry

Authors
Valérie Deffontaine
Fabian Vandermeers
Capucine Lepers
Géry Van Vyncht
Arnaud Delobel

Characterisation of the glycosylation of Humira (adalimumab) and Erbitux (Cetuximab) by high resolution mass spectrometry

Authors
Eric Largy
Fabrice Cantais
Géry Van Vyncht
Arnaud Delobel

Characterisation of Anti-HCP antibodies by 2D differential Gel Electrophoreses

Authors
Arnaud Delobel
Alix Verret
Nicolas Trinchero
Géry Van Vyncht

Scientific poster

Epitope mapping of an interleukin receptor for three therapeutic antibodies by HDX-MS

Authors
Eric Largy
Caroline Cajot
Arnaud Delobel
Location
Analytical Technologies Europe 2018

Development and optimization of a TNFα neutralizing assay using a Quality by Design approach

Authors
Fabian Vandermeers
Capucine Lepers
Florence Dusserre-Bresson
Christelle Plennevaux
Stéphanie Pennincx
Julie Nicaise
Estelle Lara
Arnaud Delobel
Location
BEBPA 2017

Absolute quantification of proteins & mAbs by ICP-MS

Authors
Julius Bianga
Philippe De Raeve
Arnaud Delobel
Location
Analytical Technologies Europe 2017

State-of-the art LC/MS methods applied to the characterisation of a highly-glycosylated fusion protein: Etanercept

Authors
Eric Largy
Fabrice Cantais
Arnaud Delobel
Location
Analytical Technologies Europe 2017

Multi-level mass spectrometric characterisation of Antibody-Drug Conjugates in a regulated environment

Authors
Eric Largy
Anicet Catrain
Arnaud Delobel
Location
Analytical Technologies Europe 2017