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State-of-the-Art MS Methods for Structural Assessment of mAbs and ADCs: From the Research Lab to Routine Characterization

Article

… Terral, A. Beck, and S. Cianferani, J Chromatogr. B , in press. R. Gahoual, A. Beck, Y.N. François, and E. … Veuthey, A Beck, and D. Guillarme, J Chromatogr. B , in press. M. Rodriguez-Aller, A. Cusumano, A Beck, D. Guillarme, and S. Fekete, J Chromatogr. B , in press. M. Sarrut, A. Corgier, S. Fekete, D. Guillarme, D. …

Congrès SEP 2023

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NLS Days 2022

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… an expert for the development of NBEs ( mAbs , ADCs , proteins ) NCEs , oligonucleotides , peptides mRNA … Validation of analytical methods as per ICH guidelines Characterisation of ADCs at intact, sub-unit and peptide …

Absolute quantification of proteins by ICP/MS

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… other hand, the LC-MS/MS determination of specific tryptic peptides lacks reproducibility due to the variability of the …

Congrès POLEPHARMA Biotesting 2024

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Advancing Gene Therapy: Enzyme Selection for Effective RNA Oligonucleotide Mapping

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Alternative analytical solutions for endotoxin and pyrogen testing

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… various (bio)pharma products such as recombinant proteins, mAbs , small molecules , peptides as well as nanoparticle …

Journées Polepharma du Biotesting 2023

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MALDI-TOF autoflex maX

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… following applications: Molecular weight determination (mAbs, ADCs, oligonucleotides, peptides, vaccines) N and O-glycan profiling and peptide mapping (mAbs) Analysis of heterogeneous compounds (e.g. PEGylated …

Characterisation of Antibody-Drug Conjugates by High-Resolution Mass Spectrometry

Resources

… a powerful tool for the characterisation of two commercial ADCs, brentuximab vedotin (Adcetris ® ) and trastuzumab … set of methods has been developed to characterise ADCs at the intact, subunit, and peptide level. These … applicable to either or both lysine- and cysteineconjugated ADCs. Herein, determination of the drug load distribution …