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2D-LC–MS for the Analysis of Monoclonal Antibodies and Antibody–Drug Conjugates in a Regulated Environment

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… the development and use for marketed monoclonal antibodies (mAbs) and antibody–drug conjugates (ADCs) of two-dimensional … environment. In recent years, monoclonal antibodies (mAbs) and antibody–drug conjugates (ADCs) have emerged as … companies in the development, release, and control of their mAbs and ADCs, in a regulated environment (such as the …

Development and validation of an antibody-drug conjugate bioassay

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… Antibody-drug conjugates (ADCs) are a class of drugs used in the treatment of different cancers. Unlike chemotherapy, ADCs are designed to only target and kill tumour cells. Structurally, ADCs are complex molecules composed of an antibody linked to …

Development and validation of an antibody-drug conjugate bioassay: application note and video

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Development and validation of an antibody-drug conjugate bioassay

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Multiple Heartcut 2D-LC/MS: a powerful tool for biopharma analysis in a regulated environment

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… of Multiple-heartcut 2D-LC/MS at Quality Assistance : Characterisation of monoclonal antibodies Characterisation of ADCs : Hydrophobic Interaction … be achieved. MS is often required to reach low LOQ, and the protein has to be removed (offline or online) before the …

Characterisation of Antibody-Drug Conjugates by High-Resolution Mass Spectrometry

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… a powerful tool for the characterisation of two commercial ADCs, brentuximab vedotin (Adcetris ® ) and trastuzumab … set of methods has been developed to characterise ADCs at the intact, subunit, and peptide level. These … applicable to either or both lysine- and cysteineconjugated ADCs. Herein, determination of the drug load distribution …

BioRN Annual Conference 2024

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… teams are here to support your developments of mAbs , ADCs and biotherapeutics . mRNA Expertise mRNA is a new …

PEGS Boston Summit

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… antibodies, we can provide full analytical support for your ADCs projects. We offer a wide range of services for all …

Swiss Biotech Day 2025

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… development and expertise in: Biotherapeutics ( mAbs , ADCs ) NCEs , oligonucleotides , peptides mRNA …

NLS Days 2022

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… an expert for the development of NBEs ( mAbs , ADCs , proteins ) NCEs , oligonucleotides , peptides mRNA … Validation of analytical methods as per ICH guidelines Characterisation of ADCs at intact, sub-unit and peptide …