2D-LC–MS for the Analysis of Monoclonal Antibodies and Antibody–Drug Conjugates in a Regulated Environment
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… monoclonal antibodies (mAbs) and antibody–drug conjugates (ADCs) of two-dimensional (2D) liquid chromatography (LC)–MS … monoclonal antibodies (mAbs) and antibody–drug conjugates (ADCs) have emerged as potent and specific anticancer agents. … (Figure 1a) (2). This heterogeneity increases with ADCs because of the conjugation of drugs, which usually …