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2D-LC–MS for the Analysis of Monoclonal Antibodies and Antibody–Drug Conjugates in a Regulated Environment

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… the development and use for marketed monoclonal antibodies (mAbs) and antibody–drug conjugates (ADCs) of two-dimensional … environment. In recent years, monoclonal antibodies (mAbs) and antibody–drug conjugates (ADCs) have emerged as … companies in the development, release, and control of their mAbs and ADCs, in a regulated environment (such as the …

Development and validation of an antibody-drug conjugate bioassay

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… Antibody-drug conjugates (ADCs) are a class of drugs used in the treatment of different cancers. Unlike chemotherapy, ADCs are designed to only target and kill tumour cells. Structurally, ADCs are complex molecules composed of an antibody linked to …

Development and validation of an antibody-drug conjugate bioassay: application note and video

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Development and validation of an antibody-drug conjugate bioassay

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Multiple Heartcut 2D-LC/MS: a powerful tool for biopharma analysis in a regulated environment

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… of monoclonal antibodies Characterisation of ADCs : Hydrophobic Interaction Chromatography (HIC) is a method of choice for the characterisation of ADCs. Due to high salt content in mobile phase, it is … (due to dilution effects) Quantification of free drugs in ADCs: Quantification of free drug in ADCs is critical for …

Characterisation of Antibody-Drug Conjugates by High-Resolution Mass Spectrometry

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… a powerful tool for the characterisation of two commercial ADCs, brentuximab vedotin (Adcetris ® ) and trastuzumab … set of methods has been developed to characterise ADCs at the intact, subunit, and peptide level. These … applicable to either or both lysine- and cysteineconjugated ADCs. Herein, determination of the drug load distribution …

BioRN Annual Conference 2024

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… our experts teams are here to support your developments of mAbs , ADCs and biotherapeutics . mRNA Expertise mRNA is a …

Festival of Biologics 2023

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… teams are here to support your developments of mAbs , ADCs and biotherapeutics . We are your analytical partner …

Festival of Biologics 2024

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… teams are here to support your developments of mAbs , ADCs and biotherapeutics . We are your analytical partner …

Knowledge For Growth 2023

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… services Bioanalytical services Elemental impurities Characterisation of proteins by MS CONTACT US TO LEARN MORE ABOUT OUR SERVICES …