Plasmid DNA vaccines
Plasmid DNA vaccines represent an evolving modality that utilise the body’s own cellular machinery to express antigens and trigger immune responses. By delivering a DNA sequence that encodes the antigen of interest, they offer flexibility, stability and rapid development timelines compared with traditional vaccines.
This technology is actively explored in infectious diseases and oncology. Developing plasmid DNA vaccines involves a complex set of analytical challenges that must be carefully addressed. From ensuring correct DNA topology to verifying sequence identity and detecting trace impurities, such as residual RNA, host cell proteins and endotoxins, each step requires rigorous testing and precise methodologies
At Quality Assistance, we design and execute regulatory-compliant analytical strategies that address these challenges, enabling you to demonstrate the safety, quality and efficacy of your plasmid DNA vaccine candidates.
Specific analytical services for plasmid DNA vaccines
We provide specific tailored analytical solutions to support the development of plasmid DNA vaccines, ensuring robust data to guide decision-making throughout the product lifecycle. Our services cover all critical aspects, including:
| Plasmid isoform (supercoiled, linear, etc.) | cGE / IEX (UV) |
|---|---|
| DNA purity | UV spectroscopy |
| DNA homogeneity | cGE / IEX (UV) |
| DNA content | UV spectroscopy |
|---|
We cover all major vaccine technologies
End-to-end analytical support for vaccines
In addition to Plasmid DNA specific assays, vaccine development requires cross-cutting services such as general quality assessment and stability studies. For a full overview of our complete capabilities, refer to our vaccines page.
Related services
Ready to partner with us ?
Your mission is to bring innovative therapies to patients, ours is to help you get there with confidence. From understanding the complexity of your product to generating reliable analytical data, we work to ensure your plasmid DNA vaccine development is built on solid scientific and analytical expertise.