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New 2D-LC/MS approaches for the analysis of in-process samples and for the characterisation of mAbs in a regulated environment

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… However, these steps are time consuming while fast characterisation is expected. On-line purification and … here and describe the use of a 2D-LC system for MS characterisation of mAbs without sample preparation. In the first application, a Protein A affinity column allows MS characterisation of mAbs …

Automate your mAbs characterisation workflows with 2D-LC/MS

Events

… Watch our webinar replay: "Automate your mAbs characterisation workflows with 2D-LC/MS" The production of monoclonal antibodies (mAbs) is a lengthy and complex process. It is, however, … would be of great benefit to quickly characterise mAbs. Recent developments in chromatographic columns have …

New 2D-LC–MS Approaches for the Analysis of In-Process Samples and for the Characterisation of mAbs in a Regulated Environment

Resources

… of antibodies is a complex and lengthy process. In-process characterisation of the mAb would help in optimising the production steps . Efficiency in mAb characterisation can be obtained by automating analysis and … complex mixtures at the intact and subunit levels using a Protein A affinity column with no sample preparation steps. …

Absolute quantification of mAbs and ADCs : forget amino acid analysis and shift to the new gold standard

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… Absolute quantification of mAbs and ADCs: Quality Assistance developed an innovative … quantification by ICP-MS/MS … Absolute quantification of mAbs and ADCs: Quality Assistance developed an innovative … quantification by ICP-MS/MS … Absolute quantification of mAbs and ADCs : forget amino acid analysis and shift to the …

State-of-the-Art MS Methods for Structural Assessment of mAbs and ADCs: From the Research Lab to Routine Characterization

Article

… IV State-of-the-Art MS Methods for Structural Assessment of mAbs and ADCs : From the Research Lab to Routine … San Francisco, from June 19 to 24. Monoclonal antibodies (mAbs) are highly complex tetrameric glycoproteins that … covalently attached via conditionally stable linkers to mAbs and are among the most promising next-generation …

Automate your mAbs characterisation workflows with 2D-LC/MS

Resources

… The production of monoclonal antibodies (mAbs) is a lengthy and complex process. It is, however, … would be of great benefit to quickly characterise mAbs. Recent developments in chromatographic columns have … for which a fast method was developed for the analysis of mAbs at the intact or subunit levels present in complex …

2D-LC/MS workflows for the automated analysis of in-process samples and for the characterization of mAbs in a GMP regulated environment

Resources

… and how advances in analytical characterisation of mAbs can help you speed up time to market of your … presentation on this topic, covering Automated analysis of mAbs in complex matrices (culture media, in-process samples) 2D-LC/MS automated characterization of mAbs at the subunit level Download the slides of the …

1D & 2D-LC/MS characterisation of mAbs for QC and stability testing

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… for each level of information you need (from intact protein to peptides/amino acids). Analytical performance of … is a very powerful technique widely used for the characterisation of biopharmaceuticals. Thanks to … antibodies, based on three levels of analysis: Intact protein, mAb substructures (after IdeS / FabRICATOR …

Development and use of 2D-LC/MS as a versatile and powerful tool for the analysis of mAbs and ADCs in a regulated environment

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… In the recent years, monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs) have emerged as … companies in the development and control of their mAbs and ADCs. … … Development and use of 2D-LC/MS as a versatile and powerful tool for the analysis of mAbs and ADCs in a regulated environment … resource …

DryLab and Empower: a successful combination for the optimisation of mAb subunit analysis

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