… of protein charge variant (SCX-RP/MS) Determination of ADCs drug to antibody ratio distribution and conjugation … isomery (HIC-RP/MS) Quantification of free drug present in ADCs (on line SPE-RP/MS) On-line sample purification by …
… a powerful tool for the characterisation of two commercial ADCs, brentuximab vedotin (Adcetris ® ) and trastuzumab … set of methods has been developed to characterise ADCs at the intact, subunit, and peptide level. These … applicable to either or both lysine- and cysteineconjugated ADCs. Herein, determination of the drug load distribution …
… manner. This kind of approach allows for detailed mAbs characterisation without the need for manual sample … of their extensive experience with the analysis of mAbs. Throughout non-clinical and clinical development, our …