
Analysis of Oligonucleotides by Size-Exclusion Chromatography: SEC-UV, SEC-MS, SEC-MALS
The field of therapeutic oligonucleotides has seen remarkable progress over the last years.
The field of therapeutic oligonucleotides has seen remarkable progress over the last years.
Biologics (monoclonal antibodies, bispecific antibodies, antibody-drug conjugates, etc.) are a class of complex molecules used in a wide range of therapeutic indications, including cancers and auto-immune diseases.
Biologics, and in particular monoclonal antibodies (mAbs), are an important class of therapeutics, and their market share keeps growing. The production of antibodies is a complex and lengthy process.
Pyrogen testing is a regulatory requirement to ensure the product quality and safety of pharmaceutical products, as pyrogens can induce life threatening fever reactions.
Monoclonal antibodies (mAbs) constitute a major and fast-growing biotherapeutic class, thanks notably to their outstanding selectivity for specific targets.
The presence of residual host cell DNA in biopharmaceutical products can induce severe side effects for patients.
Antibody-drug conjugates (ADCs) are a class of drugs used in the treatment of different cancers. Unlike chemotherapy, ADCs are designed to only target and kill tumour cells. Structurally, ADCs are complex molecules composed of an antibody linked to a cytotoxic co
The development of liquid chromatography (LC) methods has long been done using a trial-and-error approach, also known as “one factor at a time” (OFAT). While this approach is the easiest to implement, it is both time-consuming and quite inefficient.
Traditional “absolute” methods of analysis for protein quantification include colorimetry, amino acid (AA) analysis and UV-Vis spectroscopy but each of these techniques has its limitations.
Cytokine profiling is a powerful tool to link the host immune system with disease pathogenesis and/or treatment efficacy.