Robust Oligonucleotide Impurity Profiling in a GMP Setting Using the Waters SQ Detector 2 Mass Detector
Lara Nercessian
Claire Butré
Damien Mouvet
Cristian I. Cojocariub (Waters Corporation)
Jonathan Fox (Waters Corporation)
Arnaud Delobel

This study presents a reliable and easy-to-implement method using the SQ Detector 2 Mass Detector and Empower™ Software for the routine impurity analysis of oligonucleotides in QC laboratories. It offers a practical solution that meets pharmaceutical quality standards while maintaining simple and efficient workflows.