Assessing Critical Quality Attributes of AAVs Including Aggregation and Capsid Load Using a Biozen dSEC-7 Column

Assessing Critical Quality Attributes of AAVs

In this application note, we highlight the ability of the Biozen dSEC-7 SEC column to reliably resolve monomers and aggregates from two AAV serotypes using SEC-MALS in addition to enabling accurate determination of capsid and DNA molar masses, particle concentration, and percentage full AAVs in the sample.