Epitope mapping of an interleukin receptor for three therapeutic antibodies by Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS)

By
  • Eric Largy
  • Caroline Cajot
  • Arnaud Delobel
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Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) is an innovative tool for the characterisation of therapeutic monoclonal antibodies.

Besides the study of higher-order structures, HDX/MS can also be used for epitope mapping studies in order to determine to which region of the target a monoclonal antibody binds.

In this application note, we present a case study in which we performed epitope mapping for three monoclonal antibodies binding to an interleukin receptor.

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